Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) have developed a revolutionary new method to improve compact gene-editing tools known as base editors, which enable smaller, more precise DNA correction tools that may be safer for future gene therapies.
Since the 1960s, boron–dipyrromethene dyes, commonly called BODIPY dyes, have been widely used for their strong fluorescence, especially in bioimaging, molecular and ion sensing, and as photosensitizers. Researchers especially like how, with simple modifications to BODIPY molecules, their emission color can be tuned—an indispensable quality for multicolor imaging applications.
Milkweed has found a new strategy in its epic evolutionary battle with monarch butterflies: upgrading its toxins to outmaneuver the monarch's resistance. In a new study, published in the Proceedings of the National Academy of Sciences, researchers find that adding a small structural element containing nitrogen and sulfur to milkweed's toxins circumvents monarchs' ability to block them. The research sheds light on an underappreciated evolutionary tactic for plants: that not only can they increase their levels of toxicity, they can also structurally innovate to create new classes or subclasses of toxins.
The ancient city of Pompeii is one of those archaeological sites that keeps on giving with one discovery after another. While much of what we know about the Roman settlement comes from the eruption of Vesuvius in AD 79, another significant event from nearly a century earlier is also yielding fresh insights into its past.
A multinational research team led by researchers at Institute of Science Tokyo, RIKEN, and the University of Toronto has revealed how a tryptophan-rich allosteric communication network regulates receptor dynamics and activation of the human adenosine A2A receptor (A2AR), a major G protein-coupled receptor (GPCR) drug target. The study is published in the Proceedings of the National Academy of Sciences.
Air quality is expected to deteriorate across parts of Europe in the coming days, driven by an increase in microscopic polluting particles, the EU's Earth observation program said on Thursday.
Plowing, or tilling, is an age-old agricultural practice that readies the soil for planting by turning over the top layer to expose fresh earth. The method—intended to improve water and nutrient circulation—remains popular today, but concerns about soil degradation have prompted some to return to regenerative methods that disturb the soil less.
New research led by a University of Wyoming archaeologist near an ancient encampment in South America challenges a relatively new but widely accepted theory that the people who made and used Clovis points in North America were not the first inhabitants of the Americas south of the continental ice sheets.
Human genes are written in long strings of three-letter units composed of four different nucleotides. These units—or codons—specify one of many amino acids, the building blocks of proteins. Multiple codons can encode the same amino acid, which seems to point to some redundancy in our genetic code.
The bright colors of butterfly wings, the sweet aromas of flowers, and the euphonious melodies of songbirds all evolved as signals that help individuals propagate, yet humans also find these very same signals pleasing to their own senses.
