MOSAIC platform compiles chemistry protocols for faster drug design
Speeding up drug discovery in the age of AI may come down to a concept that's comfortingly old-fashioned: Consulting a chemistry recipe book.
Speeding up drug discovery in the age of AI may come down to a concept that's comfortingly old-fashioned: Consulting a chemistry recipe book.
Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine—which designs nanotechnology-based platforms for clinical translation across specialties—developed a strategy for delivering therapeutic messenger RNA (mRNA) to the inner lining of the uterus (endometrium) in mice via modified lipid nanoparticles (LNPs), which are small capsules made of fatty molecules.
As we prepare for missions beyond Earth orbit, one crucial challenge remains: keeping astronauts healthy in microgravity. Without daily exercise, their muscles, bones and cardiovascular systems weaken, which could impact mission success and astronaut safety, especially in destinations such as the moon or Mars, where crew will have to operate autonomously immediately after landing.
Girls between the ages of 13 and 19 are widely exposed to beauty content online that promotes products unsuitable for young skin—even when they are not actively seeking beauty-related information. Moreover, they believe that other girls (rather than themselves) may become insecure as a result of these videos. This is shown by research conducted by communication scientist Serena Daalmans and her colleagues at Radboud University.
Quantum key distribution (QKD) is an emerging communication technology that utilizes quantum mechanics principles to ensure highly secure communication between two parties. It enables the sender and receiver to generate a shared secret key over a channel that may be monitored by an attacker. Any attempt to eavesdrop introduces detectable errors in the quantum signals, allowing communicating parties to detect if communication is compromised via QKD protocols.
A new study shows how one of the cell's most important energy-producing machines is built. Researchers at Karolinska Institutet have mapped late steps in the formation of the human respirasome, a large protein assembly that drives mitochondrial respiration. Their research is published in the journal Nature Communications.
Peer reflection on microteaching plays a crucial role in teachers' training programs as it equips novice teachers with opportunities to understand their peers' practices. It enhances their reflective thinking, teaching awareness, and bridges the gap between theoretical and practical teaching practices.
Whether in a smartphone or laptop, semiconductors form the basis of modern electronics and accompany us constantly in everyday life. The processes taking place inside these materials are the subject of ongoing research. When the electrons in a semiconductor material are activated using light or an electrical voltage, the excited electrons also set the atomic lattice in motion. This results in collective vibrations of the atoms, known as phonons or lattice vibrations, which interact with each other and with the electrons themselves.
The kidney's proximal tubule reabsorbs water, glucose, ions and other small molecules from the urine and thus maintains the body's supply of these essential constituents. The tubule can be easily damaged by ischemia, or poor circulation, but it normally can repair itself.
Researchers from Skoltech have uncovered physical principles governing the remote "tuning" of nanocatalysts, where the ultra-thin platinum layer's properties can be controlled exclusively by modifying its metallic core's composition and structure.