Researchers identify the world's first cell line with the KMT2A::SEPTIN6 fusion gene‎

Researchers at the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures have, for the first time, identified a model cell line for a rare form of acute myeloid leukemia (AML). "The KOPM-88 cell line is, to date, the first and only known cell line worldwide to carry the KMT2A::SEPTIN6 fusion gene," explains Dr. Stefan Nagel, head of the Molecular Genetics research group in the Department of Human and Animal Cell Cultures at the DSMZ. "Thus, cancer research now has an urgently needed model system to specifically investigate this aggressive subtype of leukemia and develop novel therapeutic approaches." The work is published in the journal Cells.