How ion channels inside cells manipulate the cytoskeleton‎

Microglia, the immune cells that protect the brain, are thought to maintain a healthy brain environment by removing unwanted substances through dynamic remodeling of the actin cytoskeleton, the cell's internal framework. It has been known that microglia express Hv1/VSOP, a channel protein that transports protons, but it was believed to function at the cell membrane surface, regulating pH in its vicinity.